| What are the 9 hallmarks of aging?
To be considered as a hallmark of aging experimentally three criteria must be met: first, the hallmark must manifest itself during normal aging, second, worsening the hallmark leads to accelerated aging, and third, alleviating the hallmark leads to delay in aging and a healthier lifespan. The following hallmarks of aging are described thoroughly in the published scientific paper. You can review the paper in the link we provided above. Here we will simply name them for your reference:
Stem Cell Exhaustion
Altered intercellular communication
Genomic Instability
Telomere attrition
Epigenetic alterations
Loss of proteostasis
Deregulated nutrient sensing
Mitochondrial dysfunction
Cellular senescence
Which of these are the primary causes of damage that lead to aging?
Out of the 9 hallmarks, there are 4 that appear to be the primary causes of cellular damage that lead to aging. These are:
 1- Genomic instability
2- Telomere attrition
3- Epigenetic alterations
4- Loss of Proteostasis
These 4 hallmarks cause your body to produce responses to damage, which initially when someone is young, can compensate for the damage but in the long run these compensations lead to more damage in the form of three hallmarks.
These are the 3 “compensation” hallmarks that can be produced:
1- Deregulated nutrient sensing
2- Mitochondrial dysfunction
3- Cellular senescence
A combination between causative and compensatory hallmarks leads to what is referred as the integrative hallmarks of aging. Integrative hallmarks are viewed as the final culprits for why a young organism loses functionality and changes from a young appearance to an old appearance, and what we call aging. These last 2 hallmarks are:
1- Stem cell exhaustion
2- Altered intercellular communication
What are the interventions that may help?
 In the published paper, Maria Blasco and her collaborators provided areas of intervention that can be sought by science, to help slow the aging process, deal with the present damage found and prevent ongoing damage. The following areas of interventions are:
1- Stem cell based therapies
2- Anti-inflammatory drugs, blood borne rejuvenation factors
3- Elimination of damaged cells
4- Telomerase reactivation
5- Epigenetic drugs
6- Activation of chaperones and proteolytic systems
7- Dietary restriction, mTOR inhibition, along with AMPK and sirtuin activation
8- Mitohormetics, mitophagy
9- Clearance of senescent cells
What has RevGenetics been doing regarding these interventions?
At RevGenetics we are researching and following these strategies to combat aging. Although we can only make supplements we believe we can address and support many of these interventions. Below we provide the list of interventions once more and the products we use to support these interventions.
1- Stem cell based therapies
ProxyStem: We provide ProxyStem to support stem cells and maintaining their functionality. Medical therapies are still pretty far off, but we believe they will be available at one point because of the SENS Foundation.
2- Anti-inflammatory drugs, blood borne rejuvenation factors
MetaCurcumin: We can’t address the blood borne rejuvenation factors as a supplement company. We believe the upcoming lab we call the "Vampire Lab" will address blood borne rejuvenation factors, but ProxyStem, MetaCurcumin and Resveratrol do address some inflammatory items in this area.
3- Elimination of damaged cells
Resveratrol & PolyMAX: Elimination of damaged cells is normally done through the activation of p16 & p53 genes, which resveratrol and polymax helps with.
4- Telomerase reactivation
We believe TA-65 our recommended telomerase activator can address this item until an RNA solution is medically tested and found to be safe in humans. Our recommended telomerase activator has been found to be safe in humans, and even provided to some cancer patients by doctors we know.
5- Epigenetic drugs
Resveratrol can modulate Sirtuin protein family members, which in turn have been shown to modulate epigenetics target known to affect longevity.
6- Activation of chaperones and proteolytic systems
We are looking into this, and may provide an update in the future.
7- Dietary restriction, mTOR inhibition, along with AMPK and sirtuin activation
Resveratrol, MetaCurcumin and Polymax will help with this item, along with an intermittent 3-5 day fast.
8- Mitohormetics, mitophagy
Resveratrol: Studies on Resveratrol function through Sirtuins activation have provided convincing evidence of improved mitochondria respiration via the PGC-1 pathway.
9- Clearance of senescent cells
This may be a difficult item, and might only be addressed by specialized drugs, which no supplement maker can provide.
The future of interventions, your support and RevGenetics
While RevGenetics cannot address or support every intervention through a possible supplement, we are considering creating a new company to delve more deeply into those items we currently cannot support through because of FDA regulations. If you would like to support us, please consider purchasing our products on a monthly basis, starting today, thank you. |
